- Organisée par GenSight Biologics (EPA: SIGHT)
- Jeudi 9 juillet
- 10h00 (heure locale), 16h00 (Paris)
La conférence comprendra les présentations de deux Leaders d’Opinions Nancy Newman, MD (Emory Eye Center) et Sean Donahue, MD, PhD (Vanderbilt Children’s Hospital) qui discuteront des traitements actuels et des besoins médicaux non satisfaits dans la neuropathie optique héréditaire de Leber ( LHON). Drs. Newman et Donahue seront disponibles pour répondre aux questions à la fin de la conférence.
De plus, l’équipe de direction de GenSight fera le point sur la société et discutera des résultats des essais de phase III REVERSE et RESCUE pour LUMEVOQ® (GS010). RESCUE et REVERSE sont deux études de phase III randomisées, en double masqué, contrôlées par injection simulée (sham), conçues pour évaluer l’efficacité d’une injection intravitréenne unique de GS010 (rAAV2/2-ND4) chez des sujets atteints de la NOHL induite par la mutation G11778A du gène mitochondrial ND4. Le LUMEVOQ® (GS010) devrait être soumis à l’approbation européenne en septembre 2020.
LUMEVOQ® (GS010) cible la neuropathie optique héréditaire Leber (LHON) en s’appuyant sur une plateforme technologique propriétaire de séquence de ciblage mitochondriale (MTS) développée à partir de recherches menées à l’Institut de la Vision à Paris. La technologie permet à GS010 d’utiliser un vecteur AAV (Adeno-Associated Virus) conçu pour corriger les défauts à l’intérieur des mitochondries.
information pour rejoindre la conference
- Domestic: 1-877-705-6003
- International: 1-201-493-6725
- Conference ID: 13705257
Rejoindre la conférence : cliquer ici
Pour ceux qui ne peuvent pas écouter à ce moment, la présentation sera disponible en ligne ici.
Information Q&A
Si vous souhaitez poser une question pendant le Q&A en direct, veuillez soumettre votre demande par e-mail : Email Q&A
Biographies des leaders d’opinions
- Nancy Newman, MD
Nancy J. Newman, MD is the LeoDelle Jolley Professor of Ophthalmology, Professor of Ophthalmology and Neurology and Instructor in Neurological Surgery at the Emory University School of Medicine, where she serves as the Director of Neuro-Ophthalmology. She attended Princeton University, the University of London on a Marshall Scholarship, and Harvard Medical School. She trained in Internal Medicine and Neurology at the Massachusetts General Hospital where she was Chief Resident in Neurology, and in Neuro-Ophthalmology at the Massachusetts Eye and Ear Infirmary. She is a Fellow of the American Academy of Neurology, the American Neurological Association, and the North American Neuro-Ophthalmology Society.
She was President of the North American Neuro-Ophthalmology Society from 2014 to 2016, Chair of the Board of Directors from 2016 to 2018, and is now Senior Vice President for Education. She has served on the Editorial Boards of the American Journal of Ophthalmology, Seminars in Neurology, Journal of the Neurological Sciences and the Journal of Neuro-Ophthalmology. She has over 500 publications, including scientific articles, book chapters and books, including the primary textbook in Neuro-Ophthalmology, Walsh & Hoyt’s Clinical Neuro-Ophthalmology, 5th and 6th Editions, and the popular manual Neuro-Ophthalmology Illustrated, 1st, 2nd and 3rd Editions. She has lectured widely throughout the world and is known for her innovative teaching style. Her main research interests include disorders of the optic nerve and mitochondrial diseases. She is a Trustee Emerita of the Board of Trustees of Princeton University and also served as President of the Princeton University Alumni Association.
- Sean Donahue, MD, PhD
Sean P. Donahue, MD, PhD is currently the Vice Chair for Clinical Affairs in the Department of Ophthalmology and Visual Sciences at Vanderbilt University Medical Center in Nashville, TN. He attended College at the University of Dayton, followed by Medical and Graduate training at Emory University. Dr. Donahue was fellowship trained in Pediatric Ophthalmology and Neuro-ophthalmology at the University of Iowa after completing his residency in Ophthalmology at the University of Pittsburgh. His primary clinical interests are in the diagnosis and management of pediatric ophthalmological problems, and in the surgical management of complicated strabismus syndromes. He is a member of the American Association for Pediatric Ophthalmology and Strabismus, the American Academy of Ophthalmology, the Heed Society, the Association for Research in Strabismus (Squint Club), and the American Ophthalmological Association (AOS). He holds the inaugural Sam and Darthea Coleman Chair in Ophthalmology at Vanderbilt.
Dr. Donahue has served as the Program Chair for the American Association for Pediatric Ophthalmology and Strabismus, and on the Program Committee for the annual meetings of the North American Neuro Ophthalmology Society (NANOS) and the AOS. He has been on the Executive Committee, the Strabismus Steering Committee, and the Pediatric Optic Neuritis Study Planning Committee for the Pediatric Eye Disease Research Group. He recently served as the Protocol Chair for the Intermittent Exotropia Surgery Study, which was the first NEI-sponsored multi-centered surgical study in pediatric ophthalmology in over 30 years. He is an Executive Editor of the American Journal of Ophthalmology, and has been on the editorial boards of the Journal of AAPOS, and the Journal of Clinical Neuro ophthalmology. He has published over 300 peer-reviewed manuscripts, book chapters, and editorials, with over 100 as first author. He is widely sought-after as a guest lecturer and has spoken about clinical issues in pediatric ophthalmology on all six populated continents. He is the past winner of the NANOS Young Investigator Award (2000), a Research to Prevent Blindness Career Development Award, and the Lifetime and Senior Achievement awards from AAO and AAPOS. He was awarded the Distinguished Alumnus Award from the University of Dayton in 2015.