{"id":8470,"date":"2026-09-17T13:32:33","date_gmt":"2026-09-17T17:32:33","guid":{"rendered":"https:\/\/www.gensight-biologics.com\/mitochondrial-targeting-sequence-mts\/"},"modified":"2026-10-29T17:35:07","modified_gmt":"2026-10-29T16:35:07","slug":"mitochondrial-targeting-sequence-mts","status":"publish","type":"page","link":"https:\/\/www.gensight-biologics.com\/fr\/technologie\/mitochondrial-targeting-sequence-mts\/","title":{"rendered":"MTS (Mitochondrial Targeting Sequence)"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqvfvik7-1ec03e165995480cdb031d606a122844\">\n.avia-section.av-mqvfvik7-1ec03e165995480cdb031d606a122844{\nbackground-color:#0e1539;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-mqvfvik7-1ec03e165995480cdb031d606a122844 main_color avia-section-huge avia-no-border-styling  avia-builder-el-0  el_before_av_section  avia-builder-el-first  invalid-custom-class-found page-banner small-padding-bottom avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8470'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-gqe85-fccb89636dbb2dfeb2d251de1370f59a av_four_fifth  avia-builder-el-1  avia-builder-el-no-sibling  first flex_column_div av-animated-generic fade-in  '     ><section  class='av_textblock_section av-avwal-111f45eaa6976c364657e3be2e779bb5 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h1>Plateforme MTS (Mitochondrial Targeting Sequence)<\/h1>\n<\/div><\/section><\/div>\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2anlcv-a52e93e8086825328adca0a24434862c\">\n.avia-section.av-mr2anlcv-a52e93e8086825328adca0a24434862c{\nbackground-color:#0e1539;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-mr2anlcv-a52e93e8086825328adca0a24434862c main_color avia-section-large avia-no-border-styling  avia-builder-el-3  el_after_av_section  el_before_av_layout_row  no-padding-top-section unset-row invalid-custom-class-found avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8470'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2aovbr-48f8a695b1dba86eb929362c814682d1\">\n.avia-image-container.av-mr2aovbr-48f8a695b1dba86eb929362c814682d1 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr2aovbr-48f8a695b1dba86eb929362c814682d1 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr2aovbr-48f8a695b1dba86eb929362c814682d1 av-styling- av-hover-fade avia-align-center  avia-builder-el-4  el_before_av_two_fifth  avia-builder-el-first  top-right-dots-img animated-dots flip-dots offset-top'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-8016 avia-img-lazy-loading-not-8016 avia_image fade-basic' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/ani-dots-1.svg\" alt='' title='ani-dots-1'  height=\"500\" width=\"90\"  itemprop=\"thumbnailUrl\"  \/><img decoding=\"async\" class='wp-image-8019 avia-img-lazy-loading-not-8019 avia_image fade-overlay' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/ani-dots-2.svg\" alt='' title='ani-dots-1'  height=\"500\" width=\"90\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div>\n<div class='flex_column_table av-1d200h-18aa4012a723d1728a8312142370fa60 sc-av_two_fifth av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1d200h-18aa4012a723d1728a8312142370fa60\">\n.flex_column.av-1d200h-18aa4012a723d1728a8312142370fa60{\nwidth:37.9%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-1d200h-18aa4012a723d1728a8312142370fa60 .av-flex-placeholder{\nwidth:3.5%;\n}\n<\/style>\n<div  class='flex_column av-1d200h-18aa4012a723d1728a8312142370fa60 av_two_fifth  avia-builder-el-5  el_after_av_image  el_before_av_three_fifth  first flex_column_table_cell av-equal-height-column av-align-middle av-animated-generic left-to-right  '     ><section  class='av_textblock_section av-19j441-9162da9e4442c0c584b7178a34c22fa8 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>La plateforme propri\u00e9taire MTS de GenSight Biologics vise \u00e0 adresser les alt\u00e9rations du g\u00e9nome mitochondrial en \u00e9tendant le champ d\u2019application de la th\u00e9rapie g\u00e9nique au-del\u00e0 du noyau cellulaire. Cette technologie, actuellement appliqu\u00e9e \u00e0 la perte de vision, pourrait ouvrir une nouvelle voie th\u00e9rapeutique pour les dysfonctionnements mitochondriaux.<\/p>\n<\/div><\/section><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3skah-cd4c2b94d6da4d8c342f9d2d2a0b98ab\">\n.flex_column.av-3skah-cd4c2b94d6da4d8c342f9d2d2a0b98ab{\nwidth:58.6%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-3skah-cd4c2b94d6da4d8c342f9d2d2a0b98ab .av-flex-placeholder{\nwidth:3.5%;\n}\n<\/style>\n<div  class='flex_column av-3skah-cd4c2b94d6da4d8c342f9d2d2a0b98ab av_three_fifth  avia-builder-el-7  el_after_av_two_fifth  avia-builder-el-last  flex_column_table_cell av-equal-height-column av-align-middle av-animated-generic fade-in  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3isft-0d9e7ebb19809fbff78f293ac3ec3176\">\n.avia-video.av-3isft-0d9e7ebb19809fbff78f293ac3ec3176{\nbackground-image:url(https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/09\/MTS-page-hero-video-thumbnail.webp);\n}\n<\/style>\n<div  class='avia-video av-3isft-0d9e7ebb19809fbff78f293ac3ec3176 avia-video-16-9 av-preview-image avia-video-confirm_all av-lazyload-video-embed'  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/vimeo.com\/1230012366?fl=ip&fe=ec&share=copy'><script type='text\/html' class='av-video-tmpl'><div class='avia-iframe-wrap'><iframe loading=\"lazy\" title=\"MTS page hero video\" src=\"https:\/\/player.vimeo.com\/video\/1230012366?dnt=1&amp;app_id=122963&autoplay=1&loop=0&controls=1&muted=0\" width=\"1500\" height=\"844\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\"><\/iframe><\/div><\/script><div class='av-click-to-play-overlay'><div class=\"avia_playpause_icon\"><\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av-layout-grid-1'  class='av-layout-grid-container av-mr2blq41-edea1fa4fa86ae88dfe9d281d5c071dd entry-content-wrapper main_color av-flex-cells  avia-builder-el-9  el_after_av_section  el_before_av_section  gradient-row grid-row-not-first  container_wrap sidebar_right'  >\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2bez3w-56d882cc029eff2f64cc1af84e6462e6\">\n.flex_cell.av-mr2bez3w-56d882cc029eff2f64cc1af84e6462e6{\nvertical-align:top;\n}\n<\/style>\n<div class='flex_cell av-mr2bez3w-56d882cc029eff2f64cc1af84e6462e6 av-gridrow-cell av_one_half no_margin  avia-builder-el-10  el_before_av_cell_one_half  avia-builder-el-first  grid-img gradient-row-left-cell content-align-top'  ><div class='flex_cell_inner'><div  class='flex_column av-qm2d5-765373640983317e43b39dd9a7dde711 av_one_full  avia-builder-el-11  avia-builder-el-no-sibling  first flex_column_div  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2beepj-743bea8c65dddef94167e9b605934b6c\">\n.avia-image-container.av-mr2beepj-743bea8c65dddef94167e9b605934b6c img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr2beepj-743bea8c65dddef94167e9b605934b6c .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr2beepj-743bea8c65dddef94167e9b605934b6c av-styling- avia_animated_image av-animated-when-visible-95 fade-in avia-align-center  avia-builder-el-12  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-8481 avia-img-lazy-loading-not-8481 avia_image ' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-11.png\" alt='' title='gensight-biologics-neurons-1 1 (11)'  height=\"723\" width=\"1209\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-11.png 1209w, https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-11-300x179.png 300w, https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-11-1030x616.png 1030w, https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-11-768x459.png 768w, https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-11-705x422.png 705w\" sizes=\"(max-width: 1209px) 100vw, 1209px\" \/><\/div><\/div><\/div><\/div>\n<\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2ber73-093aa6b5617136355d08f44221d036b1\">\n.flex_cell.av-mr2ber73-093aa6b5617136355d08f44221d036b1{\nvertical-align:middle;\n}\n<\/style>\n<div class='flex_cell av-mr2ber73-093aa6b5617136355d08f44221d036b1 av-gridrow-cell av_one_half no_margin  avia-builder-el-13  el_after_av_cell_one_half  avia-builder-el-last  grid-content gradient-row-right-cell content-align-middle'  ><div class='flex_cell_inner'><div  class='flex_column av-ilzzt-98a97b9de5f778b8c2691c5e0b87f2c3 av_one_full  avia-builder-el-14  avia-builder-el-no-sibling  first flex_column_div av-animated-generic right-to-left  '     ><section  class='av_textblock_section av-mr2bdvef-75e346509b87607765d7d8624788c883 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h2>Th\u00e9rapie g\u00e9nique \u00e0 ciblage mitochondrial<\/h2>\n<h3>Le d\u00e9fi :<\/h3>\n<p>Les mutations affectant le g\u00e9nome mitochondrial alt\u00e8rent la fonction des mitochondries, organites essentiels \u00e0 la production d&rsquo;\u00e9nergie cellulaire. Du fait de l&rsquo;existence d&rsquo;un ADN mitochondrial distinct de l&rsquo;ADN nucl\u00e9aire, ces mutations \u00e9chappent aux approches classiques de th\u00e9rapie g\u00e9nique, principalement con\u00e7ues pour cibler le noyau cellulaire.<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-8l6sp-d99c00596ba6ec3662a1eb6cf25d814a\">\n#top .hr.hr-invisible.av-8l6sp-d99c00596ba6ec3662a1eb6cf25d814a{\nheight:35px;\n}\n<\/style>\n<div  class='hr av-8l6sp-d99c00596ba6ec3662a1eb6cf25d814a hr-invisible  avia-builder-el-16  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<section  class='av_textblock_section av-mrv09t06-bb246bf113c24f7397ecde9fc2105380 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>La solution :<\/h3>\n<p>La th\u00e9rapie g\u00e9nique de GenSight d\u00e9livre un g\u00e8ne dans le noyau de la cellule, o\u00f9 il est transcrit en ARN messager (ARNm). Notre technologie MTS dirige l&rsquo;ARNm vers la surface mitochondriale, o\u00f9 la prot\u00e9ine fonctionnelle n\u00e9cessaire au r\u00e9tablissement de l&rsquo;\u00e9nergie cellulaire est synth\u00e9tis\u00e9e puis transloqu\u00e9e dans la mitochondrie.<\/p>\n<\/div><\/section><\/p><\/div>\n<\/div><\/div>\n<\/div><\/p>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2iltq4-476c63730fbe76460478bf4996ba843d\">\n.avia-section.av-mr2iltq4-476c63730fbe76460478bf4996ba843d{\nbackground-color:#0e1539;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_3'  class='avia-section av-mr2iltq4-476c63730fbe76460478bf4996ba843d main_color avia-section-default avia-no-border-styling  avia-builder-el-18  el_after_av_layout_row  el_before_av_section  inner-content-dots container-bg avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8470'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-mr2iozie-c034b326496c4f0f88eb6d8765af924d av_one_full  avia-builder-el-19  avia-builder-el-no-sibling  dots-both-side-col first flex_column_div av-animated-generic bottom-to-top  '     ><section  class='av_textblock_section av-mr2io6t1-4ea6c407503d2a174104b3dc0b36716d '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock inner-text-wrap large'  itemprop=\"text\" ><h2 style=\"text-align: left;\">GS010 : notre programme MTS le plus avanc\u00e9<\/h2>\n<p>GS010 est le candidat-m\u00e9dicament de GenSight Biologics reposant sur la technologie MTS, d\u00e9velopp\u00e9 pour cibler la NOHL-<em>ND4<\/em>, forme la plus fr\u00e9quente de la Neuropathie Optique H\u00e9r\u00e9ditaire de Leber (NOHL), une maladie h\u00e9r\u00e9ditaire grave entra\u00eenant la c\u00e9cit\u00e9 et la plus r\u00e9pandue des pathologies mitochondriales au monde. Caus\u00e9e par une mutation du g\u00e8ne mitochondrial <em>ND4<\/em>, elle provoque la d\u00e9g\u00e9n\u00e9rescence des cellules ganglionnaires r\u00e9tiniennes et, par cons\u00e9quent, une perte visuelle rapide et irr\u00e9versible. GS010 vise \u00e0 r\u00e9tablir la fonction mitochondriale et \u00e0 restaurer la fonction visuelle.<\/p>\n<\/div><\/section><br \/>\n<div  class='tabcontainer av-mr2iqkq7-87e96c009de226c8658f96e6d44feff9 sidebar_tab sidebar_tab_left  avia-builder-el-21  el_after_av_textblock  el_before_av_textblock  tabs-background-color left-tabs color-tab-titles steps-tabs image-tabs border_tabs'>\n<section class='av_tab_section tab-background-image av_tab_section av-mr2iqk7q-7587d5d1c1b47eee48132c72b16825b8'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-1-tab' class='tab active_tab' role='tab' aria-selected=\"true\" tabindex=\"0\" data-fake-id='#tab-id-1' aria-controls='tab-id-1-content'  itemprop=\"headline\" >\u00c9tape 1<\/div><div id='tab-id-1-content' class='tab_content active_tab_content' role='tabpanel' aria-labelledby='tab-id-1-tab' aria-hidden=\"false\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><div class='gensight-tab-content-text'><h3>D\u00e9livrance du g\u00e8ne<\/h3>\n<p>Un vecteur AAV2 porteur d&rsquo;une copie fonctionnelle du g\u00e8ne <em>ND4<\/em>, fusionn\u00e9e \u00e0 notre MTS propri\u00e9taire, est d\u00e9livr\u00e9 aux cellules ganglionnaires r\u00e9tiniennes par injection intravitr\u00e9enne.<\/p>\n<\/div><div class='gensight-tab-image-wrap gensight-tab-video-wrap'><video class='my-tab-video' src='https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/09\/Mts-Page-Moa-Step-1.mp4' autoplay loop muted playsinline style='width:100%; height:auto;'><\/video><\/div><\/div><\/div><\/section>\n<section class='av_tab_section tab-background-image av_tab_section av-mr2iqk7q-3-adc7caa3e979402f9042379f253ae122'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-2-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-2' aria-controls='tab-id-2-content'  itemprop=\"headline\" >\u00c9tape 2<\/div><div id='tab-id-2-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-2-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><div class='gensight-tab-content-text'><h3>Adressage mitochondrial<\/h3>\n<p>Dans le noyau cellulaire, le g\u00e8ne <em>ND4<\/em> est transcrit en ARNm. Notre technologie MTS achemine cet ARNm jusqu&rsquo;\u00e0 la surface mitochondriale, o\u00f9 la prot\u00e9ine ND4 est synth\u00e9tis\u00e9e puis import\u00e9e dans la matrice mitochondriale.<\/p>\n<\/div><div class='gensight-tab-image-wrap gensight-tab-video-wrap'><video class='my-tab-video' src='https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/09\/Mts-Page-Moa-Step-2.mp4' autoplay loop muted playsinline style='width:100%; height:auto;'><\/video><\/div><\/div><\/div><\/section>\n<section class='av_tab_section tab-background-image av_tab_section av-mr2iqk7q-2-e228b5762d75617fac964687d93d4fee'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-3-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-3' aria-controls='tab-id-3-content'  itemprop=\"headline\" >\u00c9tape 3<\/div><div id='tab-id-3-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-3-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><div class='gensight-tab-content-text'><h3>Restauration \u00e9nerg\u00e9tique<\/h3>\n<p>Une fois \u00e0 l&rsquo;int\u00e9rieur de la mitochondrie, la prot\u00e9ine ND4 s&rsquo;int\u00e8gre au Complexe I de la cha\u00eene respiratoire, r\u00e9tablissant la production d&rsquo;\u00e9nergie cellulaire et prot\u00e9geant potentiellement les cellules ganglionnaires r\u00e9tiniennes contre la d\u00e9g\u00e9n\u00e9rescence.<\/p>\n<\/div><div class='gensight-tab-image-wrap gensight-tab-video-wrap'><video class='my-tab-video' src='https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/09\/Mts-Page-Moa-Step-3.mp4' autoplay loop muted playsinline style='width:100%; height:auto;'><\/video><\/div><\/div><\/div><\/section>\n<\/div><br \/>\n<section  class='av_textblock_section av-mr2n2y0h-69f2e8388a3ed74e8ce9fa44940c002f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock inner-text-wrap large'  itemprop=\"text\" ><p style=\"text-align: left;\">GS010\/LUMEVOQ\u00ae n&rsquo;a obtenu d&rsquo;autorisation de mise sur le march\u00e9 dans aucun pays et n&rsquo;est pas disponible commercialement.<\/p>\n<\/div><\/section><\/p><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2h1v7v-a8197094d7f1c7976fe73f7898c68f96\">\n.avia-section.av-mr2h1v7v-a8197094d7f1c7976fe73f7898c68f96{\nbackground-color:#0e1539;\nbackground-image:url(https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/06\/radial-2.png);\nbackground-repeat:no-repeat;\nbackground-position:0% 50%;\nbackground-attachment:scroll;\n}\n<\/style>\n<div id='av_section_4'  class='avia-section av-mr2h1v7v-a8197094d7f1c7976fe73f7898c68f96 main_color avia-section-huge avia-no-border-styling  avia-builder-el-23  el_after_av_section  el_before_av_section  flex-row avia-full-contain avia-bg-style-scroll container_wrap sidebar_right'  data-section-bg-repeat='contain'><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8470'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-gc3ox-ad9f444ce2e4c537d1f93de36fbf60ef av_one_full  avia-builder-el-24  avia-builder-el-no-sibling  first flex_column_div av-animated-generic bottom-to-top  '     ><section  class='av_textblock_section av-mrkv9yid-6771cbb3fa65892c09364f96fff35ec6 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock inner-text-wrap testimonials-note'  itemprop=\"text\" ><p style=\"text-align: center;\">Les extraits ci-dessous \u00e9manent de sources tierces et n&rsquo;engagent que leurs auteurs.<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-6srcp-0be06e2cb66f0f6551fa36ad8c73ebd9\">\n#top .hr.hr-invisible.av-6srcp-0be06e2cb66f0f6551fa36ad8c73ebd9{\nheight:70px;\n}\n<\/style>\n<div  class='hr av-6srcp-0be06e2cb66f0f6551fa36ad8c73ebd9 hr-invisible  avia-builder-el-26  el_after_av_textblock  el_before_av_testimonials '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<div  class='avia-testimonial-wrapper av-mr2h5f6f-04cd20c9cc8fb991b61e98659e1a348b avia-slider-testimonials avia-slider-2-testimonials avia_animate_when_almost_visible av-large-testimonial-slider av-slideshow-ui av-control-default av-nav-arrows-visible av-no-slider-navigation av-slider-hover-pause av-slideshow-autoplay av-loop-endless av-loop-manual-endless' data-slideshow-options=\"{&quot;animation&quot;:&quot;fade&quot;,&quot;autoplay&quot;:true,&quot;loop_autoplay&quot;:&quot;endless&quot;,&quot;interval&quot;:5,&quot;loop_manual&quot;:&quot;manual-endless&quot;,&quot;autoplay_stopper&quot;:false,&quot;noNavigation&quot;:false,&quot;bg_slider&quot;:false,&quot;keep_padding&quot;:&quot;&quot;,&quot;hoverpause&quot;:true,&quot;show_slide_delay&quot;:0}\">\n<section class=\"avia-testimonial-row\"><div class='avia-testimonial av-mr2h59u9-23fab810ab64949286bc7a2f0f0a9fee avia-testimonial-row-1 avia-first-testimonial flex_column no_margin av_one_half'><div class='avia-testimonial_inner'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia-testimonial-content '><div class='avia-testimonial-markup-entry-content'  itemprop=\"text\" ><p>\u00ab \u00c0 l\u2019heure actuelle, l\u2019expression allotopique dans le noyau d\u2019un ADNmt fonctionnel sp\u00e9cifique, associ\u00e9e \u00e0 une s\u00e9quence codante d\u2019ARNm modifi\u00e9e pour assurer l\u2019adressage mitochondrial, demeure l\u2019approche la plus proche d\u2019une transposition clinique dans ce domaine. \u00bb<\/p>\n<\/div><\/div><div class=\"avia-testimonial-meta\"><div class=\"avia-testimonial-arrow-wrap\"><div class=\"avia-arrow\"><\/div><\/div><div class='avia-testimonial-meta-mini'  itemprop=\"author\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/Person\" ><strong  class='avia-testimonial-name'  itemprop=\"name\" >Lyu L, Qie B, He Y, Chen F, Liu B.<\/strong><span  class='avia-testimonial-subtitle '  itemprop=\"jobTitle\" >Advances in gene therapy for mitochondrial genetic disorders: current status and clinical implementation challenges. J Transl Med. 2025;23:1415. Doi:10.1186\/s12967-025-07420-3<\/span><\/div><\/div><\/div><\/div>\n<\/section><div class='avia-slideshow-arrows avia-slideshow-controls' ><a href='#prev' class='prev-slide  avia-svg-icon avia-font-svg_entypo-fontello' data-av_svg_icon='left-open-big' data-av_iconset='svg_entypo-fontello' tabindex='-1' title=\"Pr\u00e9c\u00e9dent\"><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"15\" height=\"32\" viewBox=\"0 0 15 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-1' aria-describedby='av-svg-desc-1' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-1'>Pr\u00e9c\u00e9dent<\/title>\n<desc id='av-svg-desc-1'>Pr\u00e9c\u00e9dent<\/desc>\n<path d=\"M14.464 27.84q0.832 0.832 0 1.536-0.832 0.832-1.536 0l-12.544-12.608q-0.768-0.768 0-1.6l12.544-12.608q0.704-0.832 1.536 0 0.832 0.704 0 1.536l-11.456 11.904z\"><\/path>\n<\/svg><span class='avia_hidden_link_text'>Pr\u00e9c\u00e9dent<\/span><\/a><a href='#next' class='next-slide  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id=\"style-css-av-mr2g8a4l-199eb03ce213ab26e7bee92277842426\">\n.avia-section.av-mr2g8a4l-199eb03ce213ab26e7bee92277842426{\nbackground-color:#0e1539;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_5'  class='avia-section av-mr2g8a4l-199eb03ce213ab26e7bee92277842426 main_color avia-section-large avia-no-border-styling  avia-builder-el-28  el_after_av_section  el_before_av_section  unset-row flex-row no-padding-bottom no-padding-top avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8470'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-8rroh-c47ba3e9a5ec9d1dc5e858d0f1fbf442 av_one_full  avia-builder-el-29  el_before_av_one_third  avia-builder-el-first  first flex_column_div av-animated-generic fade-in  '     ><section  class='av_textblock_section av-mr2g7zh6-f18e885153a48a2062b8aae0ba182fd1 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h2 style=\"text-align: center;\">Applications potentielles<\/h2>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2go44d-97f76555bf7c0eacbc8c9e6f362300bf\">\n.flex_column.av-mr2go44d-97f76555bf7c0eacbc8c9e6f362300bf{\nwidth:31%;\n}\n<\/style>\n<div  class='flex_column av-mr2go44d-97f76555bf7c0eacbc8c9e6f362300bf av_one_third  avia-builder-el-31  el_after_av_one_full  el_before_av_one_third  icon-heading-box first flex_column_div av-animated-generic bottom-to-top  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2gfi9a-3e0ad6f52cd2a4fe0404a1848095cbe1\">\n.avia-image-container.av-mr2gfi9a-3e0ad6f52cd2a4fe0404a1848095cbe1 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr2gfi9a-3e0ad6f52cd2a4fe0404a1848095cbe1 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr2gfi9a-3e0ad6f52cd2a4fe0404a1848095cbe1 av-styling- avia-align-center  avia-builder-el-32  el_before_av_textblock  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-9786 avia-img-lazy-loading-not-9786 avia_image ' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/10\/icon-mitochondria-diseases.svg\" alt='' title='icon-mitochondria-diseases'  height=\"112\" width=\"112\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-mr2gblkx-280659a5ab21947c73470cc50a5f3729 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock small-h3'  itemprop=\"text\" ><h3 style=\"text-align: center;\">Maladies mitochondriales<\/h3>\n<\/div><\/section><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2gapm9-13e52b055a8fffb061c2fbe75903f061\">\n.flex_column.av-mr2gapm9-13e52b055a8fffb061c2fbe75903f061{\nwidth:31%;\nmargin-left:3.5%;\n}\n<\/style>\n<div  class='flex_column av-mr2gapm9-13e52b055a8fffb061c2fbe75903f061 av_one_third  avia-builder-el-34  el_after_av_one_third  el_before_av_one_third  icon-heading-box flex_column_div av-animated-generic bottom-to-top  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2gfbqz-b90867352e69fa382ecb8c22503e6be8\">\n.avia-image-container.av-mr2gfbqz-b90867352e69fa382ecb8c22503e6be8 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr2gfbqz-b90867352e69fa382ecb8c22503e6be8 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr2gfbqz-b90867352e69fa382ecb8c22503e6be8 av-styling- avia-align-center  avia-builder-el-35  el_before_av_textblock  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-9782 avia-img-lazy-loading-not-9782 avia_image ' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/10\/icon-central-nervous-system.svg\" alt='' title='icon-central-nervous-system'  height=\"112\" width=\"112\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-mr2gb83w-1c2c1c6d1d86798090e51de08335ab33 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock small-h3'  itemprop=\"text\" ><h3 style=\"text-align: center;\">Troubles du syst\u00e8me nerveux central<\/h3>\n<\/div><\/section><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2go9dj-28cc43c8ceb2a4d41110b0a63c6adb83\">\n.flex_column.av-mr2go9dj-28cc43c8ceb2a4d41110b0a63c6adb83{\nwidth:31%;\nmargin-left:3.5%;\n}\n<\/style>\n<div  class='flex_column av-mr2go9dj-28cc43c8ceb2a4d41110b0a63c6adb83 av_one_third  avia-builder-el-37  el_after_av_one_third  avia-builder-el-last  icon-heading-box flex_column_div av-animated-generic bottom-to-top  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2gfw9u-38859795b1b480e568960df169b8bb98\">\n.avia-image-container.av-mr2gfw9u-38859795b1b480e568960df169b8bb98 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr2gfw9u-38859795b1b480e568960df169b8bb98 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr2gfw9u-38859795b1b480e568960df169b8bb98 av-styling- avia-align-center  avia-builder-el-38  el_before_av_textblock  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-9784 avia-img-lazy-loading-not-9784 avia_image ' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/10\/icon-neurodegenerativ-disorders.svg\" alt='' title='icon-neurodegenerativ-disorders'  height=\"112\" width=\"112\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-mr2gbsms-1effb14525c4937cd8da65eea5cf0e68 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock small-h3'  itemprop=\"text\" ><h3 style=\"text-align: center;\">Maladies neurod\u00e9g\u00e9n\u00e9ratives<\/h3>\n<\/div><\/section><\/p><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqze5ot2-5c5b8381cad3a6f295c48613ea96aec7\">\n.avia-section.av-mqze5ot2-5c5b8381cad3a6f295c48613ea96aec7{\nbackground-color:#0e1539;\nbackground-image:url(https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-2.png);\nbackground-repeat:no-repeat;\nbackground-position:100% 0%;\nbackground-attachment:scroll;\n}\n<\/style>\n<div id='av_section_6'  class='avia-section av-mqze5ot2-5c5b8381cad3a6f295c48613ea96aec7 main_color avia-section-large avia-no-border-styling  avia-builder-el-40  el_after_av_section  avia-builder-el-last  unset-row flex-row cta-padding-row avia-full-stretch avia-bg-style-scroll container_wrap sidebar_right'  data-section-bg-repeat='stretch'><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8470'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr0wsza5-db97260da3fecc0a775e1952ea2bb9c9\">\n.avia-image-container.av-mr0wsza5-db97260da3fecc0a775e1952ea2bb9c9 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr0wsza5-db97260da3fecc0a775e1952ea2bb9c9 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr0wsza5-db97260da3fecc0a775e1952ea2bb9c9 av-styling- av-hover-fade avia-align-center  avia-builder-el-41  el_before_av_one_full  avia-builder-el-first  bottom-left-dots-img animated-dots'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-8016 avia-img-lazy-loading-not-8016 avia_image fade-basic' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/ani-dots-1.svg\" alt='' title='ani-dots-1'  height=\"500\" width=\"90\"  itemprop=\"thumbnailUrl\"  \/><img decoding=\"async\" class='wp-image-8019 avia-img-lazy-loading-not-8019 avia_image fade-overlay' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/ani-dots-2.svg\" alt='' title='ani-dots-1'  height=\"500\" width=\"90\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div>\n<div  class='flex_column av-9u3yd-9133a9441e582a2c5c152dafcd392671 av_one_full  avia-builder-el-42  el_after_av_image  avia-builder-el-last  cta-padding-col first flex_column_div av-animated-generic fade-in  '     ><section  class='av_textblock_section av-mqzdhg6h-cfa977fe63fc77e9cda57350cccce24b '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h2 style=\"text-align: center;\">Pipeline<\/h2>\n<p style=\"text-align: center;\">D\u00e9couvrez le d\u00e9veloppement clinique de GS010, notre candidat-m\u00e9dicament reposant sur la technologie MTS<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2fx46x-03a30d62552f9dfdb950d4f792b5874d\">\n#top .hr.hr-invisible.av-mr2fx46x-03a30d62552f9dfdb950d4f792b5874d{\nheight:30px;\n}\n<\/style>\n<div  class='hr av-mr2fx46x-03a30d62552f9dfdb950d4f792b5874d hr-invisible  avia-builder-el-44  el_after_av_textblock  el_before_av_button '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<div  class='avia-button-wrap av-mr2fxh03-08b7202a223c9d08f0005a3e43e4859d-wrap avia-button-center  avia-builder-el-45  el_after_av_hr  avia-builder-el-last '><a href='https:\/\/www.gensight-biologics.com\/fr\/pipeline\/'  class='avia-button av-mr2fxh03-08b7202a223c9d08f0005a3e43e4859d av-link-btn avia-icon_select-no avia-size-small avia-position-center avia-color-theme-color-highlight'   aria-label=\"En savoir plus\"><span class='avia_iconbox_title' >En savoir plus<\/span><\/a><\/div><\/p><\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_6'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8470'><div class='entry-content-wrapper clearfix'>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":8784,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-8470","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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