{"id":8485,"date":"2026-09-17T13:36:46","date_gmt":"2026-09-17T17:36:46","guid":{"rendered":"https:\/\/www.gensight-biologics.com\/optogenetics\/"},"modified":"2026-10-29T17:34:58","modified_gmt":"2026-10-29T16:34:58","slug":"optogenetics","status":"publish","type":"page","link":"https:\/\/www.gensight-biologics.com\/fr\/technologie\/optogenetics\/","title":{"rendered":"Optog\u00e9n\u00e9tique"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqvfvik7-1ec03e165995480cdb031d606a122844\">\n.avia-section.av-mqvfvik7-1ec03e165995480cdb031d606a122844{\nbackground-color:#0e1539;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-mqvfvik7-1ec03e165995480cdb031d606a122844 main_color avia-section-huge avia-no-border-styling  avia-builder-el-0  el_before_av_section  avia-builder-el-first  invalid-custom-class-found page-banner small-padding-bottom avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8485'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-gqe85-fccb89636dbb2dfeb2d251de1370f59a av_one_full  avia-builder-el-1  avia-builder-el-no-sibling  first flex_column_div av-animated-generic fade-in  '     ><section  class='av_textblock_section av-avwal-111f45eaa6976c364657e3be2e779bb5 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h1>Plateforme d&rsquo;optog\u00e9n\u00e9tique<\/h1>\n<\/div><\/section><\/div>\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2anlcv-a52e93e8086825328adca0a24434862c\">\n.avia-section.av-mr2anlcv-a52e93e8086825328adca0a24434862c{\nbackground-color:#0e1539;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-mr2anlcv-a52e93e8086825328adca0a24434862c main_color avia-section-large avia-no-border-styling  avia-builder-el-3  el_after_av_section  el_before_av_layout_row  no-padding-top-section unset-row invalid-custom-class-found avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8485'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2aovbr-14749318114d919ec52b165e693062bb\">\n.avia-image-container.av-mr2aovbr-14749318114d919ec52b165e693062bb img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr2aovbr-14749318114d919ec52b165e693062bb .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr2aovbr-14749318114d919ec52b165e693062bb av-styling- av-hover-fade avia-align-center  avia-builder-el-4  el_before_av_two_fifth  avia-builder-el-first  top-right-dots-img animated-dots flip-dots'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-8016 avia-img-lazy-loading-not-8016 avia_image fade-basic' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/ani-dots-1.svg\" alt='' title='ani-dots-1'  height=\"500\" width=\"90\"  itemprop=\"thumbnailUrl\"  \/><img decoding=\"async\" class='wp-image-8019 avia-img-lazy-loading-not-8019 avia_image fade-overlay' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/ani-dots-2.svg\" alt='' title='ani-dots-1'  height=\"500\" width=\"90\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div>\n<div class='flex_column_table av-1d200h-18aa4012a723d1728a8312142370fa60 sc-av_two_fifth av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1d200h-18aa4012a723d1728a8312142370fa60\">\n.flex_column.av-1d200h-18aa4012a723d1728a8312142370fa60{\nwidth:37.9%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-1d200h-18aa4012a723d1728a8312142370fa60 .av-flex-placeholder{\nwidth:3.5%;\n}\n<\/style>\n<div  class='flex_column av-1d200h-18aa4012a723d1728a8312142370fa60 av_two_fifth  avia-builder-el-5  el_after_av_image  el_before_av_three_fifth  first flex_column_table_cell av-equal-height-column av-align-middle av-animated-generic left-to-right  '     ><section  class='av_textblock_section av-19j441-9162da9e4442c0c584b7178a34c22fa8 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>La plateforme propri\u00e9taire d\u2019optog\u00e9n\u00e9tique de GenSight Biologics vise \u00e0 contourner la perte des photor\u00e9cepteurs en associant th\u00e9rapie g\u00e9nique et dispositif de stimulation lumineuse. Cette technologie, actuellement appliqu\u00e9e \u00e0 la perte de vision, pourrait ouvrir une nouvelle voie th\u00e9rapeutique pour les affections marqu\u00e9es par une perte de fonction cellulaire.<\/p>\n<\/div><\/section><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3skah-cd4c2b94d6da4d8c342f9d2d2a0b98ab\">\n.flex_column.av-3skah-cd4c2b94d6da4d8c342f9d2d2a0b98ab{\nwidth:58.6%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-3skah-cd4c2b94d6da4d8c342f9d2d2a0b98ab .av-flex-placeholder{\nwidth:3.5%;\n}\n<\/style>\n<div  class='flex_column av-3skah-cd4c2b94d6da4d8c342f9d2d2a0b98ab av_three_fifth  avia-builder-el-7  el_after_av_two_fifth  avia-builder-el-last  flex_column_table_cell av-equal-height-column av-align-middle av-animated-generic fade-in  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3isft-ab6f81104003a3e53b4d8d1488a355d0\">\n.avia-video.av-3isft-ab6f81104003a3e53b4d8d1488a355d0{\nbackground-image:url(https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/09\/Optogenetics-page-hero-video-thumbnail.webp);\n}\n<\/style>\n<div  class='avia-video av-3isft-ab6f81104003a3e53b4d8d1488a355d0 avia-video-16-9 av-preview-image avia-video-confirm_all av-lazyload-video-embed'  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/vimeo.com\/1230013493?fl=ip&fe=ec&share=copy'><script type='text\/html' class='av-video-tmpl'><div class='avia-iframe-wrap'><iframe loading=\"lazy\" title=\"Optogenetics page hero video\" src=\"https:\/\/player.vimeo.com\/video\/1230013493?dnt=1&amp;app_id=122963&autoplay=1&loop=0&controls=1&muted=0\" width=\"1500\" height=\"844\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\"><\/iframe><\/div><\/script><div class='av-click-to-play-overlay'><div class=\"avia_playpause_icon\"><\/div><\/div><\/div><\/div><\/div><!--close column table wrapper. Autoclose: 1 --><\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av-layout-grid-1'  class='av-layout-grid-container av-mr2blq41-edea1fa4fa86ae88dfe9d281d5c071dd entry-content-wrapper main_color av-flex-cells  avia-builder-el-9  el_after_av_section  el_before_av_section  gradient-row grid-row-not-first  container_wrap sidebar_right'  >\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2bez3w-56d882cc029eff2f64cc1af84e6462e6\">\n.flex_cell.av-mr2bez3w-56d882cc029eff2f64cc1af84e6462e6{\nvertical-align:top;\n}\n<\/style>\n<div class='flex_cell av-mr2bez3w-56d882cc029eff2f64cc1af84e6462e6 av-gridrow-cell av_one_half no_margin  avia-builder-el-10  el_before_av_cell_one_half  avia-builder-el-first  grid-img gradient-row-left-cell content-align-top'  ><div class='flex_cell_inner'><div  class='flex_column av-qm2d5-765373640983317e43b39dd9a7dde711 av_one_full  avia-builder-el-11  avia-builder-el-no-sibling  first flex_column_div  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2beepj-e7ece6278d7be20237d12f464882f6fa\">\n.avia-image-container.av-mr2beepj-e7ece6278d7be20237d12f464882f6fa img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr2beepj-e7ece6278d7be20237d12f464882f6fa .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr2beepj-e7ece6278d7be20237d12f464882f6fa av-styling- avia_animated_image av-animated-when-visible-95 fade-in avia-align-center  avia-builder-el-12  avia-builder-el-no-sibling  focus-center'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-8488 avia-img-lazy-loading-not-8488 avia_image ' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-12.png\" alt='' title='gensight-biologics-neurons-1 1 (12)'  height=\"677\" width=\"1168\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-12.png 1168w, https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-12-300x174.png 300w, https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-12-1030x597.png 1030w, https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-12-768x445.png 768w, https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-1-12-705x409.png 705w\" sizes=\"(max-width: 1168px) 100vw, 1168px\" \/><\/div><\/div><\/div><\/div>\n<\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2ber73-093aa6b5617136355d08f44221d036b1\">\n.flex_cell.av-mr2ber73-093aa6b5617136355d08f44221d036b1{\nvertical-align:middle;\n}\n<\/style>\n<div class='flex_cell av-mr2ber73-093aa6b5617136355d08f44221d036b1 av-gridrow-cell av_one_half no_margin  avia-builder-el-13  el_after_av_cell_one_half  avia-builder-el-last  grid-content gradient-row-right-cell content-align-middle'  ><div class='flex_cell_inner'><div  class='flex_column av-ilzzt-98a97b9de5f778b8c2691c5e0b87f2c3 av_one_full  avia-builder-el-14  avia-builder-el-no-sibling  first flex_column_div av-animated-generic right-to-left  '     ><section  class='av_textblock_section av-mr2bdvef-75e346509b87607765d7d8624788c883 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h2>Programmer les cellules r\u00e9tiniennes survivantes pour r\u00e9pondre \u00e0 la lumi\u00e8re<\/h2>\n<h3>Le d\u00e9fi :<\/h3>\n<p>De nombreuses pathologies c\u00e9citantes r\u00e9sultent de la d\u00e9g\u00e9n\u00e9rescence ou de la perte des photor\u00e9cepteurs, cellules sp\u00e9cialis\u00e9es charg\u00e9es de convertir les stimuli lumineux en signaux \u00e9lectrophysiologiques transmis au cerveau. Lorsque ces cellules ne sont plus fonctionnelles, la r\u00e9tine perd sa capacit\u00e9 native \u00e0 initier le traitement de l\u2019information visuelle.<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mrpd28w7-0ecb854a961ac7d0c2cb8aff8b4a2b03\">\n#top .hr.hr-invisible.av-mrpd28w7-0ecb854a961ac7d0c2cb8aff8b4a2b03{\nheight:35px;\n}\n<\/style>\n<div  class='hr av-mrpd28w7-0ecb854a961ac7d0c2cb8aff8b4a2b03 hr-invisible  avia-builder-el-16  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<section  class='av_textblock_section av-mrv0ape4-b63fea68f3ec5c9afb9c5cd6e41cddf5 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>La solution :<\/h3>\n<p>La plateforme d\u2019optog\u00e9n\u00e9tique de GenSight Biologics vise \u00e0 compenser la perte des photor\u00e9cepteurs en conf\u00e9rant une sensibilit\u00e9 lumineuse \u00e0 des cellules r\u00e9tiniennes survivantes. Notre th\u00e9rapie g\u00e9nique induit l\u2019expression d\u2019une prot\u00e9ine photosensible dans les cellules ganglionnaires r\u00e9tiniennes, tandis que notre dispositif optronique capture l\u2019environnement visuel et projette une lumi\u00e8re dont la longueur d\u2019onde et l\u2019intensit\u00e9 sont adapt\u00e9es pour activer ces cellules et restaurer une r\u00e9ponse visuelle fonctionnelle.<\/p>\n<\/div><\/section><\/p><\/div>\n<\/div><\/div>\n<\/div><\/p>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2iltq4-476c63730fbe76460478bf4996ba843d\">\n.avia-section.av-mr2iltq4-476c63730fbe76460478bf4996ba843d{\nbackground-color:#0e1539;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_3'  class='avia-section av-mr2iltq4-476c63730fbe76460478bf4996ba843d main_color avia-section-default avia-no-border-styling  avia-builder-el-18  el_after_av_layout_row  el_before_av_section  inner-content-dots container-bg avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8485'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-mr2iozie-c034b326496c4f0f88eb6d8765af924d av_one_full  avia-builder-el-19  avia-builder-el-no-sibling  dots-both-side-col first flex_column_div av-animated-generic bottom-to-top  '     ><section  class='av_textblock_section av-mr2io6t1-4ea6c407503d2a174104b3dc0b36716d '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock inner-text-wrap large'  itemprop=\"text\" ><h2 style=\"text-align: left;\">GS030 : notre programme d&rsquo;optog\u00e9n\u00e9tique le plus avanc\u00e9<\/h2>\n<p style=\"text-align: left;\">GS030 est le candidat-m\u00e9dicament de GenSight Biologics reposant sur l\u2019optog\u00e9n\u00e9tique, d\u00e9velopp\u00e9 pour cibler la R\u00e9tinite Pigmentaire (RP), la maladie r\u00e9tinienne h\u00e9r\u00e9ditaire la plus r\u00e9pandue au monde. GS030 vise \u00e0 restaurer une fonction visuelle, ind\u00e9pendamment des plus de 100 g\u00e8nes pouvant \u00eatre \u00e0 l\u2019origine de la maladie.<\/p>\n<\/div><\/section><br \/>\n<div  class='tabcontainer av-mr2iqkq7-87e96c009de226c8658f96e6d44feff9 sidebar_tab sidebar_tab_left  avia-builder-el-21  el_after_av_textblock  el_before_av_textblock  tabs-background-color left-tabs color-tab-titles steps-tabs image-tabs border_tabs'>\n<section class='av_tab_section tab-background-image av_tab_section av-mr2iqk7q-657805a2f4b7e431caf9d80bcbb77464'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-1-tab' class='tab active_tab' role='tab' aria-selected=\"true\" tabindex=\"0\" data-fake-id='#tab-id-1' aria-controls='tab-id-1-content'  itemprop=\"headline\" >\u00c9tape 1<\/div><div id='tab-id-1-content' class='tab_content active_tab_content' role='tabpanel' aria-labelledby='tab-id-1-tab' aria-hidden=\"false\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><div class='gensight-tab-content-text'><h3>D\u00e9livrance du g\u00e8ne<\/h3>\n<p>Un vecteur AAV2 porteur du g\u00e8ne codant la prot\u00e9ine photosensible ChrimsonR est d\u00e9livr\u00e9 aux cellules ganglionnaires r\u00e9tiniennes par injection intravitr\u00e9enne.<\/p>\n<\/div><div class='gensight-tab-image-wrap gensight-tab-video-wrap'><video class='my-tab-video' src='https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/09\/Optogenetics-Page-Moa-Step-1.mp4' autoplay loop muted playsinline style='width:100%; height:auto;'><\/video><\/div><\/div><\/div><\/section>\n<section class='av_tab_section tab-background-image av_tab_section av-mr2iqk7q-3-8b3f065c410aacc022d8ad22c5c4ee74'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-2-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-2' aria-controls='tab-id-2-content'  itemprop=\"headline\" >\u00c9tape 2<\/div><div id='tab-id-2-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-2-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><div class='gensight-tab-content-text'><h3>Expression d\u2019une opsine photosensible<\/h3>\n<p>Les cellules ganglionnaires r\u00e9tiniennes cibl\u00e9es expriment la prot\u00e9ine ChrimsonR \u00e0 leur membrane plasmique, transformant ces cellules en capteurs de lumi\u00e8re fonctionnels.<\/p>\n<\/div><div class='gensight-tab-image-wrap gensight-tab-video-wrap'><video class='my-tab-video' src='https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/09\/Optogenetics-Page-Moa-Step-2.mp4' autoplay loop muted playsinline style='width:100%; height:auto;'><\/video><\/div><\/div><\/div><\/section>\n<section class='av_tab_section tab-background-image av_tab_section av-mr2iqk7q-2-ad4b9a501e02a7c427f030470134da48'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-3-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-3' aria-controls='tab-id-3-content'  itemprop=\"headline\" >\u00c9tape 3<\/div><div id='tab-id-3-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-3-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><div class='gensight-tab-content-text'><h3>Stimulation lumineuse<\/h3>\n<p>La prot\u00e9ine ChrimsonR \u00e9tant activ\u00e9e par une lumi\u00e8re ambre de forte intensit\u00e9, un dispositif de stimulation lumineuse est utilis\u00e9 pour obtenir une activation significative. Nos lunettes optroniques GS030-MD capturent la sc\u00e8ne visuelle au moyen d&rsquo;une cam\u00e9ra int\u00e9gr\u00e9e, traitent les informations en temps r\u00e9el via un logiciel embarqu\u00e9, puis projettent un faisceau lumineux pr\u00e9cis sur la r\u00e9tine trait\u00e9e afin de stimuler les cellules rendues photosensibles.<\/p>\n<\/div><div class='gensight-tab-image-wrap gensight-tab-video-wrap'><video class='my-tab-video' src='https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/09\/Optogenetics-Page-Moa-Step-3.mp4' autoplay loop muted playsinline style='width:100%; height:auto;'><\/video><\/div><\/div><\/div><\/section>\n<\/div><br \/>\n<section  class='av_textblock_section av-mr2n2y0h-69f2e8388a3ed74e8ce9fa44940c002f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock inner-text-wrap large'  itemprop=\"text\" ><p style=\"text-align: left;\">GS030 n&rsquo;a obtenu d&rsquo;autorisation de mise sur le march\u00e9 dans aucun pays et n&rsquo;est pas disponible commercialement.<\/p>\n<\/div><\/section><\/p><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2h1v7v-5ceebd9cbc44869a6bed1d02008dedc4\">\n.avia-section.av-mr2h1v7v-5ceebd9cbc44869a6bed1d02008dedc4{\nbackground-color:#0e1539;\nbackground-image:url(https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/06\/radial-2.png);\nbackground-repeat:no-repeat;\nbackground-position:0% 50%;\nbackground-attachment:scroll;\n}\n<\/style>\n<div id='av_section_4'  class='avia-section av-mr2h1v7v-5ceebd9cbc44869a6bed1d02008dedc4 main_color avia-section-huge avia-no-border-styling  avia-builder-el-23  el_after_av_section  el_before_av_section  flex-row medium-padding-bottom avia-full-contain avia-bg-style-scroll container_wrap sidebar_right'  data-section-bg-repeat='contain'><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8485'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-gc3ox-ad9f444ce2e4c537d1f93de36fbf60ef av_one_full  avia-builder-el-24  avia-builder-el-no-sibling  first flex_column_div av-animated-generic bottom-to-top  '     ><section  class='av_textblock_section av-mrpd2ln8-db37b92b9343a9f2b6bacb25fd337bd5 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock inner-text-wrap testimonials-note'  itemprop=\"text\" ><p style=\"text-align: center;\">Les extraits ci-dessous \u00e9manent de sources tierces et n&rsquo;engagent que leurs auteurs.<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-a3xjs-3917ea75a8b29f702c5f2f8ad900d509\">\n#top .hr.hr-invisible.av-a3xjs-3917ea75a8b29f702c5f2f8ad900d509{\nheight:70px;\n}\n<\/style>\n<div  class='hr av-a3xjs-3917ea75a8b29f702c5f2f8ad900d509 hr-invisible  avia-builder-el-26  el_after_av_textblock  el_before_av_testimonials '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<div  class='avia-testimonial-wrapper av-mr2h5f6f-04cd20c9cc8fb991b61e98659e1a348b avia-slider-testimonials avia-slider-2-testimonials avia_animate_when_almost_visible av-large-testimonial-slider av-slideshow-ui av-control-default av-nav-arrows-visible av-no-slider-navigation av-slider-hover-pause av-slideshow-autoplay av-loop-endless av-loop-manual-endless' data-slideshow-options=\"{&quot;animation&quot;:&quot;fade&quot;,&quot;autoplay&quot;:true,&quot;loop_autoplay&quot;:&quot;endless&quot;,&quot;interval&quot;:5,&quot;loop_manual&quot;:&quot;manual-endless&quot;,&quot;autoplay_stopper&quot;:false,&quot;noNavigation&quot;:false,&quot;bg_slider&quot;:false,&quot;keep_padding&quot;:&quot;&quot;,&quot;hoverpause&quot;:true,&quot;show_slide_delay&quot;:0}\">\n<section class=\"avia-testimonial-row\"><div class='avia-testimonial av-mr2h59u9-5d79d43abef4946ad4a152e797416478 avia-testimonial-row-1 avia-first-testimonial flex_column no_margin av_one_half'><div class='avia-testimonial_inner'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia-testimonial-content '><div class='avia-testimonial-markup-entry-content'  itemprop=\"text\" ><p>\u00ab Les approches th\u00e9rapeutiques visant \u00e0 stimuler ces cellules r\u00e9siduelles, ind\u00e9pendamment de la cause g\u00e9n\u00e9tique sous-jacente, pourraient permettre de restaurer la fonction visuelle chez les patients pr\u00e9sentant une perte de vision avanc\u00e9e, et b\u00e9n\u00e9ficier \u00e0 bien plus de patients que les th\u00e9rapies ciblant le g\u00e8ne sp\u00e9cifique impliqu\u00e9 dans chaque maladie. \u00bb<\/p>\n<\/div><\/div><div class=\"avia-testimonial-meta\"><div class=\"avia-testimonial-arrow-wrap\"><div class=\"avia-arrow\"><\/div><\/div><div class='avia-testimonial-meta-mini'  itemprop=\"author\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/Person\" ><strong  class='avia-testimonial-name'  itemprop=\"name\" > De Silva SR, Moore AT. <\/strong><span  class='avia-testimonial-subtitle '  itemprop=\"jobTitle\" > Optogenetic approaches to therapy for inherited retinal degenerations. J Physiol. 2022;600(21):4623\u201332. Doi:10.1113\/JP282076<\/span><\/div><\/div><\/div><\/div>\n<\/section><div class='avia-slideshow-arrows avia-slideshow-controls' ><a href='#prev' class='prev-slide  avia-svg-icon avia-font-svg_entypo-fontello' data-av_svg_icon='left-open-big' data-av_iconset='svg_entypo-fontello' tabindex='-1' title=\"Pr\u00e9c\u00e9dent\"><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"15\" height=\"32\" viewBox=\"0 0 15 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-1' aria-describedby='av-svg-desc-1' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-1'>Pr\u00e9c\u00e9dent<\/title>\n<desc id='av-svg-desc-1'>Pr\u00e9c\u00e9dent<\/desc>\n<path d=\"M14.464 27.84q0.832 0.832 0 1.536-0.832 0.832-1.536 0l-12.544-12.608q-0.768-0.768 0-1.6l12.544-12.608q0.704-0.832 1.536 0 0.832 0.704 0 1.536l-11.456 11.904z\"><\/path>\n<\/svg><span class='avia_hidden_link_text'>Pr\u00e9c\u00e9dent<\/span><\/a><a href='#next' class='next-slide  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id=\"style-css-av-mr2g8a4l-aca50c0904d6594a497a8dc4a0fe0092\">\n.avia-section.av-mr2g8a4l-aca50c0904d6594a497a8dc4a0fe0092{\nbackground-color:#0e1539;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_5'  class='avia-section av-mr2g8a4l-aca50c0904d6594a497a8dc4a0fe0092 main_color avia-section-large avia-no-border-styling  avia-builder-el-28  el_after_av_section  el_before_av_section  unset-row flex-row no-padding-bottom avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8485'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-8rroh-c47ba3e9a5ec9d1dc5e858d0f1fbf442 av_one_full  avia-builder-el-29  el_before_av_one_third  avia-builder-el-first  first flex_column_div av-animated-generic fade-in  '     ><section  class='av_textblock_section av-mr2g7zh6-f18e885153a48a2062b8aae0ba182fd1 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h2 style=\"text-align: center;\">Applications potentielles<\/h2>\n<\/div><\/section><\/div><div class='flex_column_table av-mr2gapm9-82fb3b52439b45defc699c0b7ecf4ae0 sc-av_one_third av-equal-height-column-flextable'>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2gapm9-82fb3b52439b45defc699c0b7ecf4ae0\">\n.flex_column.av-mr2gapm9-82fb3b52439b45defc699c0b7ecf4ae0{\nwidth:31%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-mr2gapm9-82fb3b52439b45defc699c0b7ecf4ae0 .av-flex-placeholder{\nwidth:3.5%;\n}\n<\/style>\n<div  class='flex_column av-mr2gapm9-82fb3b52439b45defc699c0b7ecf4ae0 av_one_third  avia-builder-el-31  el_after_av_one_full  el_before_av_one_third  icon-heading-box first flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2gfbqz-c9c5716e7ce6dbe7e800b3d659dc88e1\">\n.avia-image-container.av-mr2gfbqz-c9c5716e7ce6dbe7e800b3d659dc88e1 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr2gfbqz-c9c5716e7ce6dbe7e800b3d659dc88e1 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr2gfbqz-c9c5716e7ce6dbe7e800b3d659dc88e1 av-styling- avia-align-center  avia-builder-el-32  el_before_av_textblock  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-9790 avia-img-lazy-loading-not-9790 avia_image ' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/10\/icon-retinal-diseases.svg\" alt='' title='icon-retinal-diseases'  height=\"112\" width=\"112\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-mr2gb83w-1c2c1c6d1d86798090e51de08335ab33 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock small-h3'  itemprop=\"text\" ><h3 style=\"text-align: center;\">Maladies r\u00e9tiniennes<\/h3>\n<\/div><\/section><\/p><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2go44d-e782c769242a05d41825ba3567087e76\">\n.flex_column.av-mr2go44d-e782c769242a05d41825ba3567087e76{\nwidth:31%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-mr2go44d-e782c769242a05d41825ba3567087e76 .av-flex-placeholder{\nwidth:3.5%;\n}\n<\/style>\n<div  class='flex_column av-mr2go44d-e782c769242a05d41825ba3567087e76 av_one_third  avia-builder-el-34  el_after_av_one_third  el_before_av_one_third  icon-heading-box flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2gfi9a-fff9d7e1985ddd852fe9eaf0f1517835\">\n.avia-image-container.av-mr2gfi9a-fff9d7e1985ddd852fe9eaf0f1517835 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr2gfi9a-fff9d7e1985ddd852fe9eaf0f1517835 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr2gfi9a-fff9d7e1985ddd852fe9eaf0f1517835 av-styling- avia-align-center  avia-builder-el-35  el_before_av_textblock  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-9782 avia-img-lazy-loading-not-9782 avia_image ' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/10\/icon-central-nervous-system.svg\" alt='' title='icon-central-nervous-system'  height=\"112\" width=\"112\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-mr2gblkx-280659a5ab21947c73470cc50a5f3729 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock small-h3'  itemprop=\"text\" ><h3 style=\"text-align: center;\">Troubles du syst\u00e8me nerveux central<\/h3>\n<\/div><\/section><\/p><\/div><div class='av-flex-placeholder'><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2go9dj-28cc43c8ceb2a4d41110b0a63c6adb83\">\n.flex_column.av-mr2go9dj-28cc43c8ceb2a4d41110b0a63c6adb83{\nwidth:31%;\nmargin-left:0;\n}\n#top .flex_column_table.av-equal-height-column-flextable.av-mr2go9dj-28cc43c8ceb2a4d41110b0a63c6adb83 .av-flex-placeholder{\nwidth:3.5%;\n}\n<\/style>\n<div  class='flex_column av-mr2go9dj-28cc43c8ceb2a4d41110b0a63c6adb83 av_one_third  avia-builder-el-37  el_after_av_one_third  avia-builder-el-last  icon-heading-box flex_column_table_cell av-equal-height-column av-align-top av-animated-generic bottom-to-top  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2gfw9u-38859795b1b480e568960df169b8bb98\">\n.avia-image-container.av-mr2gfw9u-38859795b1b480e568960df169b8bb98 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr2gfw9u-38859795b1b480e568960df169b8bb98 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr2gfw9u-38859795b1b480e568960df169b8bb98 av-styling- avia-align-center  avia-builder-el-38  el_before_av_textblock  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-9784 avia-img-lazy-loading-not-9784 avia_image ' src=\"https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/10\/icon-neurodegenerativ-disorders.svg\" alt='' title='icon-neurodegenerativ-disorders'  height=\"112\" width=\"112\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-mr2gbsms-1effb14525c4937cd8da65eea5cf0e68 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock small-h3'  itemprop=\"text\" ><h3 style=\"text-align: center;\">Maladies neurod\u00e9g\u00e9n\u00e9ratives<\/h3>\n<\/div><\/section><\/p><\/div><\/div><!--close column table wrapper. Autoclose: 1 -->\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mqze5ot2-5c5b8381cad3a6f295c48613ea96aec7\">\n.avia-section.av-mqze5ot2-5c5b8381cad3a6f295c48613ea96aec7{\nbackground-color:#0e1539;\nbackground-image:url(https:\/\/www.gensight-biologics.com\/wp-content\/uploads\/2026\/07\/gensight-biologics-neurons-1-2.png);\nbackground-repeat:no-repeat;\nbackground-position:100% 0%;\nbackground-attachment:scroll;\n}\n<\/style>\n<div id='av_section_6'  class='avia-section av-mqze5ot2-5c5b8381cad3a6f295c48613ea96aec7 main_color avia-section-large avia-no-border-styling  avia-builder-el-40  el_after_av_section  avia-builder-el-last  unset-row flex-row cta-padding-row avia-full-stretch avia-bg-style-scroll container_wrap sidebar_right'  data-section-bg-repeat='stretch'><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8485'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr0wsza5-db97260da3fecc0a775e1952ea2bb9c9\">\n.avia-image-container.av-mr0wsza5-db97260da3fecc0a775e1952ea2bb9c9 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mr0wsza5-db97260da3fecc0a775e1952ea2bb9c9 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mr0wsza5-db97260da3fecc0a775e1952ea2bb9c9 av-styling- av-hover-fade avia-align-center  avia-builder-el-41  el_before_av_one_full  avia-builder-el-first  bottom-left-dots-img animated-dots'   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-8016 avia-img-lazy-loading-not-8016 avia_image fade-basic' 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le d\u00e9veloppement clinique de GS030, notre candidat-m\u00e9dicament reposant sur l\u2019optog\u00e9n\u00e9tique<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mr2fx46x-03a30d62552f9dfdb950d4f792b5874d\">\n#top .hr.hr-invisible.av-mr2fx46x-03a30d62552f9dfdb950d4f792b5874d{\nheight:30px;\n}\n<\/style>\n<div  class='hr av-mr2fx46x-03a30d62552f9dfdb950d4f792b5874d hr-invisible  avia-builder-el-44  el_after_av_textblock  el_before_av_button '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<div  class='avia-button-wrap av-mr2fxh03-08b7202a223c9d08f0005a3e43e4859d-wrap avia-button-center  avia-builder-el-45  el_after_av_hr  avia-builder-el-last '><a href='https:\/\/www.gensight-biologics.com\/fr\/pipeline\/'  class='avia-button av-mr2fxh03-08b7202a223c9d08f0005a3e43e4859d av-link-btn avia-icon_select-no avia-size-small avia-position-center avia-color-theme-color-highlight'   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